Weiser-Evans Laboratory

SELECTED PUBLICATIONS

2023

Smooth muscle-derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner.
Allison M Dubner, Sizhao Lu, Austin J Jolly, Keith A Strand, Marie F Mutryn, Tyler Hinthorn, Tysen Noble, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary Cm Weiser-Evans
JCI insight  ·  22 Nov 2023
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research-Brief Report.
Allison M Dubner, Sizhao Lu, Austin J Jolly, Tysen Noble, Tyler Hinthorn, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary C M Weiser-Evans
Arteriosclerosis, thrombosis, and vascular biology  ·  14 Sep 2023
Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis.
Austin J Jolly, Sizhao Lu, Allison M Dubner, Keith A Strand, Marie F Mutryn, Aaron Pilotti-Riley, Etienne P Danis, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary Cm Weiser-Evans
JCI insight  ·  08 May 2023

2022

Lgals3-Transitioned Inflammatory Smooth Muscle Cells: Major Regulators of Atherosclerosis Progression and Inflammatory Cell Recruitment
Sizhao Lu, Mary C.M. Weiser-Evans
Arteriosclerosis, Thrombosis, and Vascular Biology  ·  07 Jul 2022

2021

Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodeling.
Austin J Jolly, Sizhao Lu, Keith A Strand, Allison M Dubner, Marie F Mutryn, Raphael A Nemenoff, Mark W Majesky, Karen S Moulton, Mary C M Weiser-Evans
Cardiovascular research  ·  14 May 2021

2020

Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis.
Sizhao Lu, Austin J Jolly, Keith A Strand, Allison M Dubner, Marie F Mutryn, Karen S Moulton, Raphael A Nemenoff, Mark W Majesky, Mary Cm Weiser-Evans
JCI insight  ·  03 Dec 2020
High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling.
Keith A Strand, Sizhao Lu, Marie F Mutryn, Linfeng Li, Qiong Zhou, Blake T Enyart, Austin J Jolly, Allison M Dubner, Karen S Moulton, Raphael A Nemenoff, Keith A Koch, Daniel V LaBarbera, Mary C M Weiser-Evans
Arteriosclerosis, thrombosis, and vascular biology  ·  25 Jun 2020

2019

PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report.
Sizhao Lu, Keith A Strand, Marie F Mutryn, Rebecca M Tucker, Austin J Jolly, Seth B Furgeson, Karen S Moulton, Raphael A Nemenoff, Mary C M Weiser-Evans
Arteriosclerosis, thrombosis, and vascular biology  ·  19 Dec 2019

2018

PTEN deficiency promotes pathological vascular remodeling of human coronary arteries.
Karen S Moulton, Marcella Li, Keith Strand, Shawna Burgett, Penn McClatchey, Rebecca Tucker, Seth B Furgeson, Sizhao Lu, Bruce Kirkpatrick, Joseph C Cleveland, Raphael A Nemenoff, Amrut V Ambardekar, Mary Cm Weiser-Evans
JCI insight  ·  22 Feb 2018

2016

Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4.
Mark W Majesky, Henrick Horita, Allison Ostriker, Sizhao Lu, Jenna N Regan, Ashim Bagchi, Xiu Rong Dong, Joanna Poczobutt, Raphael A Nemenoff, Mary C M Weiser-Evans
Circulation research  ·  09 Nov 2016
Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation.
Henrick Horita, Christina L Wysoczynski, Lori A Walker, Karen S Moulton, Marcella Li, Allison Ostriker, Rebecca Tucker, Timothy A McKinsey, Mair E A Churchill, Raphael A Nemenoff, Mary C M Weiser-Evans
Nature communications  ·  04 Mar 2016

2014

Vascular smooth muscle cell-derived transforming growth factor-β promotes maturation of activated, neointima lesion-like macrophages.
Allison Ostriker, Henrick N Horita, Joanna Poczobutt, Mary C M Weiser-Evans, Raphael A Nemenoff
Arteriosclerosis, thrombosis, and vascular biology  ·  13 Feb 2014

2013

Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension.
Henrick Horita, Seth B Furgeson, Allison Ostriker, Kyle A Olszewski, Timothy Sullivan, Leah R Villegas, Michelle Levine, Jane E Parr, Carlyne D Cool, Raphael A Nemenoff, Mary C M Weiser-Evans
Journal of the American Heart Association  ·  31 May 2013

2011

Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.
Henrick N Horita, Peter A Simpson, Allison Ostriker, Seth Furgeson, Vicki Van Putten, Mary C M Weiser-Evans, Raphael A Nemenoff
Arteriosclerosis, thrombosis, and vascular biology  ·  22 Sep 2011
SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation.
Raphael A Nemenoff, Henrick Horita, Allison C Ostriker, Seth B Furgeson, Peter A Simpson, Vicki VanPutten, Joseph Crossno, Stefan Offermanns, Mary C M Weiser-Evans
Arteriosclerosis, thrombosis, and vascular biology  ·  17 Mar 2011

2010

Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
Seth B Furgeson, Peter A Simpson, Insun Park, Vicki Vanputten, Henrick Horita, Christopher D Kontos, Raphael A Nemenoff, Mary C M Weiser-Evans
Cardiovascular research  ·  05 Jan 2010

2008

Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.
Raphael A Nemenoff, Peter A Simpson, Seth B Furgeson, Nihal Kaplan-Albuquerque, Joseph Crossno, Pamela J Garl, James Cooper, Mary C M Weiser-Evans
Circulation research  ·  13 Mar 2008